Hospital Queen Elizabeth II | A+ A A- | Biru Ungu Hijau Oren Merah
Pilihan Bahasa : English Bahasa Melayu
Facebook Feed
Pekeliling JPA

JPA PPSPP

Pekeliling Kemajuan Pentadbiran Awam

Pekeliling Kemajuan Pentadbiran Awam

Warga HQE II
Warganegara
Warga Asing
Bancian
Apakah nama yang sesuai untuk menggantikan nama Hospital Queen Elizabeth II?
Hospital Bandaraya Kota Kinabalu (HBKK) 56% (745)
Hospital Damai Kota Kinabalu (HDKK) 33% (442)
Hospital Damai Luyang (HDL) 9% (124)
Jumlah Undian: 1311
Bancian ini akan ditutup pada 2017/9/20 3:05
Komen?

Artikel > Media > The extent of neuronal loss in the brain during MS

The extent of neuronal loss in the brain during MS

A study by researchers from Queen Mary University of London establishes for the first time the extent of neuronal loss in the brain of a person with MS over their life, and finds that demyelination may not be as good an indicator of disease progression as previously thought.

By dissecting and analysing brains from nine people with MS and seven healthy controls using gold standard techniques, they found that the mean number of neurons was 14.9 billion in MS versus 24.4 billion in controls -- a 39% difference.

The density of neurons in MS was smaller by 28%, and cortical volume by 26%, and they found that the whole brain was affected equally.

Importantly, the number of neurons was strongly associated with the thickness of the cortex, which is something that can be measured by MRI. The decline in volume of the cortex could therefore be detected in vivo and be used to predict neuronal loss in patients or measure neurodegeneration during clinical trials.

Lead researcher Klaus Schmierer said: "Given that we found no association between neuronal loss and demyelination, trying to detect demyelinating lesions in the cortex -- an area of research strongly driven by the availability of high field MRI systems -- may be of lesser importance than measuring cortical volume and getting on with early active treatment."

As cortical neuronal loss is responsible for cognitive and other functions, which occur early in MS, the researchers say that to avoid neurodegeneration, early treatment is key.


Story Source:

Materials provided by Queen Mary University of London. Note: Content may be edited for style and length.


Journal Reference:

  1. D Carassiti, D R Altmann, N Petrova, B Pakkenberg, F Scaravilli, K Schmierer. Neuronal loss, demyelination and volume change in the multiple sclerosis neocortex. Neuropathology and Applied Neurobiology, 2017; DOI: 10.1111/nan.12405
 

Navigasi Artikel
Previous article 'Smart contact lens sensor' for diabetic and glaucoma diagnosis Long-term aspirin use doesn't lower risk of stroke for some a-fib patients Next article
Carian
Intranet

Sistem Intranet

Garis Panduan EKSA

Garis Panduan EKSA height=

1GovUC Outlook Web App

1GovUC OWA

iSPAAA

iSPAAA

Maklum balas daripada orang awam berkenaan perkhidmatan KKM

 

Kalendar Aktiviti
Oktober 2017
Ah Is Se Ra Kh Ju Sa
1 2 3 4 5 6 7
8 9 10 11 12 13 14
15 16 17 18 19 20 21
22 23 24 25 26 27 28
29 30 31        
Tahukah Anda ?
Penyakit jantung merupakan penyebab kematian UTAMA di Malaysia manakala Strok pada kedudukan ke-4.
Kod QR HQE2

QEH2 QR Code

Imbas menggunakan

telefon bimbit

atau

PDA (Smartphone)


Hak Cipta Terpelihara Hospital Queen Elizabeth II 2017 Dasar Privasi | Dasar Keselamatan

PENAFIAN
Hospital Queen Elizabeth II tidak akan bertanggungjawab ke atas sebarang kehilangan atau kerosakan yang diakibatkan oleh penggunaan maklumat yang dicapai daripada portal ini.